Mathematical Modeling and Yeast Oxidative Stress Project @ VBI

This systems biology project is a collaboration between the Laubenbacher, Mendes and Shulaev labs at the Virginia Bioinformatics Institute. Our aim is to develop new techniques to construct integrative mathematical models of biological systems, and we will focus on the yeast Saccharomyces cerevisiae oxidative stress response as an example.

This integrative project consists of two major areas:

Modeling: The Laubenbacher group is developing methods to create top-down models of biological systems using discrete mathematics . The Mendes group is developing methods based on ((Continuous Methods|(continuous) nonlinear dynamics)) to create top-down models of biological systems. Both methods are being developed with simulated data and with the results of our own yeast systems biology experiments (below).

Experimental

• growth experiments (Shulaev and Mendes groups)
• transcriptomics (Shulaev group and VBI's CLF)
• Proteomics (Shulaev group and VBI's CLF)
• metabolomics (Shulaev group)
• mutants

Private project pages

Project team

Links

• Conferences

This project is funded by the NIGMS under grant number RO1 GM068947-01